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La Agente 'Optima' enables persistent Bayesian optimization in SDLs

La Agente 'Optima' is an agentic framework that manages Bayesian optimization campaigns across systems, maintaining a persistent state and separating reasoning from execution, improving automation and auditability.

By OpenSmartRoute editorial · written through the router by llm-onprem

From arXiv cs.AI - “La Agente \'Optima: Towards Agentic Self-Driving Laboratories

La Agente 'Optima' introduces an agentic framework designed for self-driving laboratories (SDLs). It constructs and supervises Bayesian optimization campaigns across both computational and experimental systems, maintaining a persistent optimization state.

The framework separates large language model (LLM) reasoning from campaign execution. This allows 'Optima' to run repetitive optimization loops consistently, only involving the agent when interpretation or campaign revision is necessary. Every decision remains auditable.

Evaluation of 'Optima' included ablation studies, digital discovery tasks, and physical platforms. It successfully adapted campaigns as scientific problems and environments evolved, such as correcting measurement failures and optimizing chemical yields.

Results indicate that 'Optima' can perform rigorous, long-term optimization campaigns with less resource use than human-directed efforts, making advanced optimization accessible to domain scientists without specialized setup.

Source: https://arxiv.org/abs/2609.04564

Published Sep 7, 2026 · updated Sep 7, 2026 · 125 words

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