opentargets-skill

Imported from openai/plugins (plugins/life-science-research/skills/opentargets-skill/SKILL.md). Install upstream with npx skills add openai/plugins --skill opentargets-skill. Copyright stays with the author.

Operating rules

• Use scripts/opentargets_graphql.py for all Open Targets GraphQL work.
• Use scripts/opentargets_disease_heatmap.py when the user wants the associated-disease bubble grid or a disease-by-datasource evidence matrix.
• The script accepts max_items; for nested GraphQL results, start with max_items=3 to 5.
• Keep GraphQL selection sets narrow and page connection-style fields conservatively.
• Use query_path for long GraphQL documents instead of pasting large inline query strings.
• Re-run requests in long conversations instead of relying on earlier tool output.
• Treat displayed ... in tool previews as UI truncation, not part of the real query.

Execution behavior

• Return concise markdown summaries from the script JSON by default.
• Return the JSON verbatim only if the user explicitly asks for machine-readable output.
• Prefer targeted GraphQL queries that select only the fields needed for the user task.
• Use schema introspection only when necessary; do not dump large schema payloads into chat.
• For the associated-disease heatmap, treat datasourceScores as evidence-source breadth/context. Do not treat heatmap breadth alone as proof of causal target assignment, mechanism, or direction of effect.

Input

• Read one JSON object from stdin.
• Required field: query or query_path
• Optional fields: variables, max_items, max_depth, timeout_sec, save_raw, raw_output_path
• Common Open Targets patterns:
  • {"query":"query { __typename }"}
  • {"query":"query searchAny($q: String!) { search(queryString: $q) { total hits { entity score object { ... on Target { id approvedSymbol } } } } }","variables":{"q":"MST1"},"max_items":3}

Output

• Success returns ok, source, top_keys, a compact summary, and raw_output_path when save_raw=true.
• Failure returns ok=false with error.code such as invalid_json, invalid_input, network_error, invalid_response, or graphql_error.

Execution

echo '{"query":"query { __typename }"}' | python scripts/opentargets_graphql.py

Associated-disease heatmap helper:

echo '{
  "ensembl_id":"ENSG00000186868",
  "page_size":50,
  "max_pages":4,
  "disease_name_filter":"alzh"
}' | python scripts/opentargets_disease_heatmap.py

The helper paginates associatedDiseases, collects datasourceScores, and returns:

• matrix.columns: datasource IDs plus display labels
• matrix.rows: diseases with datasource_scores
• summary.rows_preview: top datasource signals per disease

Use the disease-name filter as a client-side substring filter similar to the UI. If you later need the overall association score column, inspect the GraphQL row type first before adding candidate fields such as score or associationScore.

References

• No additional runtime references are required; keep the import package limited to this file and the bundled scripts in scripts/.